1609Plasma markers of immune activation likely reflect related but distinct processes of cellular immune activation in HIV-infected persons before and after suppression of viremia by antiretroviral therapy: ACTG 5260
نویسندگان
چکیده
distinct processes of cellular immune activation in HIV-infected persons before and after suppression of viremia by antiretroviral therapy: ACTG 5260 Theodoros Kelesidis, MD, PhD; Carlee Moser, PhD; Grace A. Mccomsey, MD; Todd Brown, MD, PhD; Heather Ribaudo, PhD; Thuy Tien T Tran; Otto Yang MD; James Stein, MD; Judith Currier, MD, MSc; David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA; Harvard School of Public Health, Boston, MA; Case Western Reserve University School of Medicine, Cleveland, OH; University Hospitals Case Medical Center, Cleveland, OH; Johns Hopkins University, Baltimore, MD; University of Wisconsin School of Medicine and Public Health, MADISON, WI; University of California Los Angeles, Los Angeles, CA
منابع مشابه
Metabolic and Immune Activation Effects of Treatment Interruption in Chronic HIV-1 Infection: Implications for Cardiovascular Risk
BACKGROUND Concern about costs and antiretroviral therapy (ART)-associated toxicities led to the consideration of CD4 driven strategies for the management of HIV. That approach was evaluated in the SMART trial that reported an unexpected increase of cardiovascular events after treatment interruption (TI). Our goal was to evaluate fasting metabolic changes associated with interruption of antiret...
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Antiretroviral therapy (ART) reduces levels of HIV-1 and immune activation but both can persist despite clinically effective ART. The relationships among pre-ART and on-ART levels of HIV-1 and activation are incompletely understood, in part because prior studies have been small or cross-sectional. To address these limitations, we evaluated measures of HIV-1 persistence, inflammation, T cell act...
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The advent of combination antiretroviral therapies has altered the clinical course of HIV infection such that successful suppression of HIV replication typically results in sufficient restoration of immune function to protect most patients from the opportunistic complications that have defined AIDS. Yet a substantial proportion of treated HIV infected persons fail to increase circulating CD4 T ...
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عنوان ژورنال:
دوره 1 شماره
صفحات -
تاریخ انتشار 2014